B-cell precursor ALL is a clonal, malignant disease involving blast cells that express antigens such as CD192

  • B-cell precursor ALL is characterized by the accumulation of blast cells that suppresses hematopoiesis
  • CD19 is a cell-surface protein that regulates the immune response3
  • Many B-cell ALL blast cells express CD19, a cell-surface protein expressed on both normal B cells and many B-cell malignancies2
  • CAR T-cell therapy engineers a patient’s own T cells, enabling them to target and kill malignant B cells such as B-cell precursor ALL2,4

TECARTUS is a single-infusion, autologous cellular therapy designed for patients with R/R B-cell precursor ALL, a CD19-expressing malignancy with a high circulating tumor burden1,2

TECARTUS® mechanism of action
  1. Target Binding Domain—binds to CD19 on the surface of B cells1,5

  2. CD28 Co-stimulatory Domain

    • CD28 augments T-cell receptor signaling to drive cytokine production and T-cell proliferation1,5
  3. CD3-ζ Activation Domain—activates T cell1,5


TECARTUS binds to CD19-expressing cancer cells and normal B cells1

TECARTUS® binding to cells

Upon engagement with target cells, the co-stimulatory domains activate downstream signaling cascades that result in

  • T-cell activation, proliferation, and acquisition of effector functions
  • Secretion of inflammatory cytokines and chemokines
Killing of cells
This sequence of events leads to the killing of
CD19-expressing cells

TECARTUS manufacturing process: successfully and reliably manufactured for patients with R/R B-cell precursor ALL1

MEDIAN 16-day TURNAROUND TIME from leukapheresis
to product release
(range: 11-39 days)

92% MANUFACTURING SUCCESS RATE*

SINGLE-DOSE, ONE-TIME INFUSION

*In the ZUMA-3 trial, 6 patients did not receive TECARTUS due to manufacturing failure.1

ALL=acute lymphoblastic leukemia; CAR=chimeric antigen receptor; R/R=relapsed or refractory.

References: 1. TECARTUS® (brexucabtagene autoleucel). Prescribing information. Kite Pharma, Inc; 2021. 2. Witkowski MT, Lasry A, Carroll WL, Aifantis I. Immune-based therapies in acute leukemia. Trends Cancer. 2019;5(10):604-618. 3. Blanc V, Bousseau A, Caron A, Carrez C, Lutz RJ, Lambert JM. SAR3419: an anti-CD19-maytansinoid immunoconjugate for the treatment of B-cell malignancies. Clin Cancer Res. 2011;17(20):6448-6458. 4. Kochenderfer JN, Rosenberg SA. Treating B‑cell cancer with T cells expressing anti-CD19 chimeric antigen receptors. Nat Rev Clin Oncol. 2013;10(5):267-276. 5. Feins S, Kong W, William EF, Milone MC, Fraietta JA. An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer. Am J Hematol. 2019;94(S1):S3-S9.